CONEXUS will co-produce, structure and promote access to contextualised knowledge by co-creating Nature-Based Solutions (NBS) to support the restoration of urban ecosystems. Cities in Europe and Latin America share urgent global-local challenges to integrate practical actions with strategies to achieve greater inclusion, biodiversity, climate change adaptation and environmental quality. CONEXUS brings together community, private, public and research partners to experiment with novel co-production methods to deliver NBS innovations in ‘Life-Lab’ pilots, using a place-based approach to solve problems together with citizens (in São Paulo, Bogotá, Santiago, Buenos Aires, Lisbon, Barcelona and Turin). The combined palette of socio-cultural, ecological and governance contexts presents the opportunity to move forward faster together, and to inform changes in urban policy and practice.